With FlashFXP 4.2.0.1730 under Windows 7 X64, I get very slow responsiveness while using the arrow keys or tab/shift+tab to navigate the interface using the NVDA screen reader.
This works correctly in 4.1.8.1701.
To reproduce this, you'll need the NVDA screen reader from
http://nvda-project.org.
With NVDA running, launch FlashFXP. Accept the evaluation dialog if it appears, and you should land in the list of local files.
Press the down and up arrows to move through the files, and there is a large delay before NVDA reads the file information. Tab through the interface, and the delay is still there.
If the same steps are repeated with 4.1.8.1701, the delay is gone.