It sounds like the as yet unsolved lockup issue... Can you be specific about what the machine you are experiencing this on is? Multi-cpu? Dual Core? XP/Vista?
Do you have trouble getting directory listings for people already logged in after you notice the problem?
One other thing. Bring up the site and issue "site crashnow" from a M account. It should generate a crashlog and dump files and the process should die. Next time the site goes crazy try to issue a site crashnow. If it doesn't actually crash then you have found the same problem I rarely see. Kill the process in task manager and restart since you can't shut it down normally at this point...
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