In 99% of the cases when that error msg appears is when you try to upload (or make changes) to a dir/drive that is a part of a (in ioFTPD) raided dir. Uploading is not supported because it is intended for archiving purposes only. But uploading still "works" but everything ends up on the last drive in that perticular vfs raid. For example:
"d:\ftp\somedir" /somedir <-- the dir you want to make changes to is located here
"e:\ftp\someotherdir" /somedir <-- uploads end up here
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